Daidzin

SKU: orb1304870

Description

Daidzin

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 552-66-9
• MW: 416.38
• Purity: 99.43%
• Formula: C₂₁H₂₀O₉
• SMILES: OC[C@H]1O[C@@H](Oc2ccc3c(c2)occ(-c2ccc(O)cc2)c3=O)[C@H](O)[C@@H](O)[C@@H]1O
• Target: Reverse Transcriptase,Mitochondrial Metabolism,Dehydrogenase
• Solubility: DMSO:252 mg/mL (605.22 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (12.01 mM);Ethanol:4 mg/mL (9.61 mM)

Bioactivity

• Target IC50:
  ALDH1:20 nM(Ki)
• In Vivo:
  Daidzin has no effect on alcohol-metabolizing enzymes(i.e., ADH and ALDH) when given to rats intragastrically. Chronic daidzin administration exerts an effect on alcohol pharmacokinetics, althoug the effect is less pronounced than whe the compound is administered concurrently with ethanol.The compound is shown to shorten sleep time if ethanol is given intragastrically, but not when given intraperitoneally, indicating absence of effect on ethanol elimination rate. Daidzin delays ethanol absorption and lessens alcohol intoxication the compound is shown to suppres the levels of BAC(blood alcohol concentration fo the first 3 hr after alcohol ingestion In both fasted and fed rats. These effects of daidzin may in part be due to its antioxidant activit.
• In Vitro:
  Daidzin, a glycoside of daidzein, increase the transcriptional activity of RARα and RARγ but does not bind to the RAR. Daidzin does not inhibit human class Ⅰ, Ⅱ, or Ⅲ alcohol dehydrogenases, nor does it have any significant effect on biological systems that are known to be affected by Other isoflavones. Daidzin inhibits human ALDH-I and ALDH-II in a concentration dependent manner. Daidzin inhibits both ALDH-I and ALDH-II in an apparently competitive manner with Ki Values of 40 nM and 20 μM, respectively and it inhibits ALDH-I uncompetitively with respect to NAD+ the Inhibition of ALDH-I by daidzin is reversibl.
• Cell Research:
  CV-1 cells are transfected with 100 ng ERE-Luc and 50 ng ER-RARα or ER-RARγ. Transfected cells are treated wit the indicated isoflavone at 0.5, 1, 10, 50, and 100 μM for 24 h the β-Gal activity is used to normalize luciferase activity. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Reverse Transcriptase, ReverseTranscriptase, inhibit, Inhibitor, NPI-031D, MitochondrialMetabolism, Mitochondrial Metabolism, Daidzin, Daidzoside, Daidzein 7-glucoside, Daidzein 7-O-glucoside, ALDH-Ⅰ, ALDH-Ⅱ

Compound Identifiers

PubChem CID

107971