DA-0157

SKU: orb2944976

Description

DA-0157 is a dual EGFR/ALK inhibitor designed to combat resistance mutations in NSCLC, showing potent in vitro activity against models like EGFR Del19/T790M/C797S and ALK-L1196M. It demonstrates oral bioavailability and antitumor efficacy in mouse models, supporting its use in preclinical oncology research.

Research Area

Cardiovascular Research, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2756978-82-0
• MW: 656.597
• Formula: C₃₁H₄₃BrN₇O₂P
• SMILES: O=P(C1=CC(=CC=C1NC2=NC(=NC=C2Br)NC=3C=C(C(=CC3OC)N4CCC(N5CCN(C)CC5)CC4)C)C)(C)C
• Target: Cytochromes P450,ALK,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166930932