(D)-PPA 1

SKU: orb1679390

Description

This small molecule inhibitor selectively binds PD-L1 with a Kd of 0.51 µM, blocking the PD-1/PD-L1 interaction. It is validated in flow cytometry-based cellular assays and demonstrates efficacy in preclinical cancer models by inhibiting tumor growth and improving survival in vivo.

Key Properties

• CAS Number: 1620813-53-7
• MW: 1555.67
• Formula: C₇₀H₉₈N₂₀O₂₁
• SMILES: C([C@H](NC([C@H](NC([C@@H](CC1=CC=C(O)C=C1)NC([C@@H](CC(N)=O)N)=O)=O)CO)=O)CCCCN)(=O)N2[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](CC3=CC=C(O)C=C3)C(N[C@H](CC4=CN=CN4)C(N[C@H](CC5=CC=CC=C5)C(O)=O)=O)=O)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CC(O)=O)=O)[C@H](C)O)=O)CCC2

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

156593962