D-glutamine

SKU: orb1300742

Description

D-glutamine

Research Area

Cell Biology, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 5959-95-5
• MW: 146.14
• Purity: 99.99%
• Formula: C₅H₁₀N₂O₃
• SMILES: [H][C@@](N)(CCC(N)=O)C(O)=O
• Target: Mitophagy,GluR,Ferroptosis,Endogenous Metabolite,Autophagy
• Solubility: DMSO:Insoluble;H2O:10 mM

Bioactivity

• In Vivo:
  Glutamine shows the greatest benefit when administered at doses greater than 0.35 g/kg/day, with optimal benefit potentially occurring at 0.5 g/kg/day.
• In Vitro:
  In catabolic states of injury and illness, glutamine becomes conditionally-essential (requiring intake from food or supplements). Glutamine is the most abundant naturally occurring, non-essential amino acid in the human body and one of the few amino acids that can directly cross the blood–brain barrier. Glutamine is a key pharmaconutrient in the body's response to stress and injury. Glutamine exerts its protective effects via multiple mechanisms, including direct protection of cells and tissue from injury, attenuation inflammation, and preservation of metabolic function.
• Cell Research:
  Effect of D-Glutamine and glutaminase inhibitor on acetaldehyde-induced permeability. Caco-2 cell monolayers are incubated for 4 h without or with acetaldehyde (600 μM) and L-Glutamine or D-Glutamine (2 mM) in the absence or presence of 6-diazo-5-oxo-L-norleucine (DON). Transepithelial electrical resistance (TER) and FITC-inulin flux are measured. Values are means±SE (n=6).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, D glutamine, Dglutamine, D-glutamine, D-Glutamine, GluR, Ferroptosis, Endogenous Metabolite, EndogenousMetabolite, Inhibitor, Mitochondrial Autophagy, Mitophagy, inhibit

Compound Identifiers

PubChem CID

145815