CZC-54252 hydrochloride

SKU: orb1303563

Description

CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor, demonstrating IC50 values of 1.85 nM (wild-type) and 1.28 nM (G2019S mutant). It exhibits neuroprotective properties in cellular models, attenuating G2019S LRRK2-induced neuronal injury with an EC50 of 1 nM, making it a valuable research tool for Parkinson's disease studies.

Research Area

Cell Biology

Key Properties

• CAS Number: 1784253-05-9
• MW: 541.45
• Purity: 98.21% (May vary between batches)
• Formula: C₂₂H₂₆Cl₂N₆O₄S
• SMILES: Cl.COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCOCC1
• Target: LRRK2
• Solubility: DMSO:30 mg/mL (55.41 mM)

Bioactivity

• Target IC50:
  LRRK2 (wild-type):1.28 nM (IC50)|LRRK2 (G2019S):1.85 nM (IC50)
• In Vitro:
  CZC-54252 hydrochloride(1.6 nM) fully reverses G2019S LRRK2-induced human neuronal injury to wild-type levels. CZC-54252 hydrochloride inhibits the recombinant human wild-type LRRK2 with an IC50 ranging from 1 to 5 nM. CZC-54252 hydrochloride inhibits the G2019S mutant with an IC50 ranging from 2 to 7 nM in a TF-FRET assay.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CZC 54252, CZC 54252 hydrochloride, CZC 54252 Hydrochloride, CZC54252, CZC-54252, CZC54252 hydrochloride, CZC54252 Hydrochloride, CZC-54252 Hydrochloride, inhibit, LRRK2-G2019S, LRRK2, neuronal, neuroprotective, G2019S LRRK2, Leucine-rich repeat kinase 2, injury, Inhibitor

Compound Identifiers

PubChem CID

90488950