CZC-25146 hydrochloride

SKU: orb1302057

Description

CZC-25146 hydrochloride

Research Area

Cell Biology

Key Properties

• CAS Number: 1330003-04-7
• MW: 525
• Purity: 98.76%
• Formula: C₂₂H₂₆ClFN₆O₄S
• SMILES: Cl.COc1cc(ccc1Nc1ncc(F)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCOCC1
• Target: LRRK2
• Solubility: DMSO:55 mg/mL (104.76 mM)

Bioactivity

• Target IC50:
  LRRK2 (WT):4.76 nM|LRRK2 (G2019S):6.87 nM
• In Vivo:
  CZC-25146 possesses favorable pharmacokinetic properties, such as a volume of distribution of 5.4 L/kg and clearance of 2.3 L/hr/kg that render it suitable for in-vivo studies.
• In Vitro:
  CZC-25146 inhibited only five kinases(PLK4, GAK, TNK1, CAMKK2, and PIP4K2C) with high potency. CZC-25146 neither caused cytotoxicity in human cortical neurons at concentration below 5 μM over a seven-day treatment in culture nor did it block neuronal development in vitro

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

CZC 25146, CZC 25146 Hydrochloride, CZC 25146 hydrochloride, CZC25146, CZC-25146, CZC25146 Hydrochloride, CZC25146 hydrochloride, CZC-25146 Hydrochloride, Parkinson's disease, neurons, liver diseases, LRRK2 (WT), LRRK2 G2019S, LRRK2 (G2019S), LRRK2, inflammatory, inhibit, Leucine-rich repeat kinase 2, Inhibitor

Compound Identifiers

PubChem CID

72193880