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    Cytochrome C Antibody

    Cytochrome C Antibody

    Catalog Number: orb749740

    DispatchUsually dispatched within 5-10 working days
    $ 764.00
    Catalog Numberorb749740
    CategoryAntibodies
    DescriptionCytochrome c is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3.
    Species/HostMouse
    ClonalityMonoclonal
    Clone Number6H2.B4
    Tested applicationsFACS, IF
    ReactivityHuman, Mouse, Rat
    IsotypeMouse IgG1, kappa
    ImmunogenRat full-length protein was used as the immunogen for the Cytochrome C antibody.
    Dilution rangeFlow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml
    PurityProtein G affinity chromatography
    ConjugationUnconjugated
    Formula0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
    Hazard InformationThis Cytochrome C antibody is available for research use only.
    UniProt IDP99999
    StorageStore the Cytochrome C antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
    Buffer/Preservatives0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced) and 0.05% sodium azide
    NoteFor research use only
    Application notesOptimal dilution of the Cytochrome C antibody should be determined by the researcher.
    Expiration Date12 months from date of receipt.
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