Cytembena

SKU: orb1700776

Description

Cytembena is a cytostatic and carcinogenic small molecule that broadly inhibits DNA biosynthesis, potentially increasing fibroadenoma incidence. It is used in research to study chemotherapeutic mechanisms and carcinogenesis in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 21739-91-3
• MW: 307.07
• Purity: 99.35% (May vary between batches)
• Formula: C₁₁H₈BrNaO₄
• SMILES: COC1=CC=C(C(/C(Br)=C\C([O-])=O)=O)C=C1.[Na+]
• Target: DNA/RNA Synthesis
• Solubility: DMSO:60 mg/mL (195.4 mM)

Bioactivity

• In Vivo:
  Cytembena was given i.p. in doses of 5, 10, 20, 40, and 80 mg/kg body wt. to Wistar rats and in doses of 20, 40, and 80 mg/kg body wt. to ICR mice and to Chinese hamsters. Five patients with various types of malignancy, so far medically untreated, received 20 mg Cytembena/kg body wt i.v. A combination of Cytembena and cyclophosphamide was applied i.p. in single equal doses 1: 1 of 5,10, 20, and 40 mg/kg body wt to ICR mice, Chinese hamsters, and Wistar rats. Patients were given i.v. 20 mg Cytembena and 20 mg cyclophosphamide/kg body wt. Bone marrow cells were examined 24 h after the administration. The frequency of abnormal metaphases and chromosomal breaks after Cytembena treatment was low; nonetheless, the indicated dose-effect relationship was found in all the rodents used. The frequency of chromosomal breaks was 2-3 times higher in rodents in comparison with men, after treatment with a dose of 20 mg Cytembena/kg body wt. The highest frequencies of induced aberrations were found in mice. The rodents appeared to be 3--4 times more sensitive to the induction of chromosomal breaks and abnormal metaphases than men, after a dose of 20 mg Cytembena and 20 mg cyclophosphamide/kg body wt.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RNA Synthesis, RNASynthesis, DNA synthesis, DNA Synthesis, DNASynthesis, Cytembena

Compound Identifiers

PubChem CID

23665583