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CYP1B1-IN-9

SKU: orb3135572

Description

CYP1B1-IN-9 is a highly selective and competitive CYP1B1 inhibitor, with IC50 values of 1.48 nM for CYP1B1, and greater than 100 μM and 80 μM for CYP1A1 and CYP1A2, respectively. This compound effectively inhibits the migration and invasion of A549/T cells, offers the potential to resensitize paclitaxel-resistant cells, and exhibits good metabolic stability and safety, as well as favorable pharmacokinetic properties. CYP1B1-IN-9 is applicable in research on tumor resistance.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number3077254-39-5
MW383.68
FormulaC16H9Cl3N2OS
SMILESO=C(NC=1C=C(Cl)C=C(Cl)C1)C2=NC(=CS2)C=3C=CC=C(Cl)C3
TargetCytochromes P450

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

CYP1B1-IN-9 (orb3135572)

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