Cynomolgus Integrin alpha 8 beta 1 (ITGA8&ITGB1) Heterodimer Protein, His Tag&Tag Free (MALS verified)

SKU: orb3158263

Description

Human Integrin alpha 8 beta 1 Heterodimer Protein consists of ITGA8 and ITGB1. The integrin alpha 8 subunit, isolated by low stringency hybridization, is a novel integrin subunit that associates with beta 1. The recently identified alpha 8 integrin subunit associates with beta 1 and is predominantly expressed in smooth muscle and other contractile cells in adult tissues, and in mesenchymal and neural cells during development. In addition, Integrin alpha 8 beta 1 is a receptor for fibronectin and can promote attachment, cell spreading, and neurite outgrowth on fibronectin.

Research Area

Neuroscience; Immunology & Inflammation

Images & Validation

• Application Notes:
  Cynomolgus ITGA8&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA8 and ITGB1, has a calculated MW of 114.6 kDa (ITGA8) & 83.6 kDa (ITGB1). Subunit ITGA8 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The protein migrates as 130-150 kDa (ITGA8) and 100-125 kDa (ITGB1) when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

• Expression System: HEK293
• Target: Integrin alpha 8 beta 1
• Reactivity: Monkey
• Tag: C-10×His | Native
• Molecular Weight: 114.6 kDa (ITGA8) & 83.6 kDa (ITGB1)
• Expression Region: Phe 39 - Leu 1012 (ITGA8) & Gln 161 - Asp 868 (ITGB1)
• Purity: 95%
• Endotoxins: 1.0 EU per μg
• Conjugation: Unconjugated

Storage & Handling

• Storage: -20°C
• Form/Appearance: Powder
• Buffer/Preservatives: 50 mM HEPES, 150 mM NaCl, pH 7.5
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Integrin alpha 8 beta 1

RefSeq:ITGB1, A0A7N9D0D7, ITGA8, XP_005564768.3