Cyclopentenylcytosine

• Catalog Number: orb2564419
• Category: Small Molecules
• Description: Cyclopentenylcytosine (CPC), a nucleoside analog, effectively inhibits CTP synthetase, leading to reduced levels of cytidine triphosphate (CTP) and deoxycytidine triphosphate (dCTP) in leukemic cells. Furthermore, it enhances the phosphorylation of 1-β-D-arabinorubosylmannosylcytidine (araC) and increases its DNA intercalation activity. In the human T lymphocyte line MOLT-3, cyclopentenylcytosine triggers apoptosis and necrosis in a dose (50-300 nM) and time (8-16 h) dependent manner. When used in conjunction with araC, cyclopentenylcytosine augments the induction of both apoptosis and necrosis, amplifying its cytotoxic effects on T lymphoblasts.
• CAS Number: 90597-22-1
• Purity: 98.00%
• MW: 239.23
• SMILES: O[C@H]1[C@@H](C=C(CO)[C@H]1O)N2C(=O)N=C(N)C=C2
• Formula: C₁₀H₁₃N₃O₄
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.