α-Cyano-4-hydroxycinnamic acid(α-CHCA)

SKU: orb1220373

Description

α-Cyano-4-hydroxycinnamic acid (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 : 1.5 μM).

Key Properties

• CAS Number: 28166-41-8
• MW: 189.17
• Purity: >98% (HPLC)
• Formula: C₁₀H₇NO₃
• SMILES: N#C/C(=C\c1ccc(O)cc1)C(=O)O
• Target: Monocarboxylate Transporter
• Solubility: DMSO:37mg/mL(195.59mM)

Bioactivity

• In Vitro:
  α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) inhibits monocarboxylates transport such as lactate and pyruvate. α-Cyano-4-hydroxycinnamic acid (CHC; 0.5 mM and 1 mM) of 1 mM has a significant inhibitory effect on branching morphogenesis and decreases the epithelial perimeter and area of lung explants in a dose dependent way. At 100 μM concentration, α-Cyano-4-hydroxycinnamic acid rapidly and almost totally inhibits O2 uptake by rat heart mitochondria oxidizing pyruvate. Inhibition can be detected at concentrations of inhibitor as low as 1 μM although inhibition took time to develop at this concentration.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Monocarboxylate Transporter