Coryneine

SKU: orb1296895

Description

Coryneine is a quaternary ammonium alkaloid derived from dopamine, isolated from aconite root. It serves as a research tool in pharmacological studies, particularly in investigating adrenergic and cholinergic receptor interactions in both in vitro and in vivo experimental models.

Key Properties

• CAS Number: 7224-66-0
• MW: 196.27
• Purity: 98.09%
• Formula: C₁₁H₁₈NO₂
• SMILES: C(C[N+](C)(C)C)C1=CC(O)=C(O)C=C1
• Target: Others
• Solubility: DMSO:70 mg/mL (356.65 mM)

Bioactivity

• In Vivo:
  Coryneine (20-150 microM) blocked the nerve-evoked twitch response without affecting the contraction evoked by electrical stimulation of the muscle. Coryneine (20 microM-2mM) itself depolarized the endplate membrane and this effect was reversibly suppressed by 1 and 5 microM pancuronium. Coryneine 30 microM-10mM) produced contractions of denervated muscles in a concentration-dependent manner and the effects were reduced by 70nM pancuronium.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Quaternary dopamine, Trimethyl(3,4-dihydroxyphenethyl)aminium, 2-(3,4-dihydroxyphenyl)ethyl-trimethylazanium, Dopamine methiodide, Coryneine

Compound Identifiers

PubChem CID

165581