Compound BAY-0069

SKU: orb1741337

Description

BAY-0069 is a potent and selective PPARγ transactivator, demonstrating inhibitory activity with IC50 values of 6.3 nM (human) and 24 nM (murine). This compound serves as a valuable research tool for investigating PPARγ-related pathways in cancer, applicable in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 420826-65-9
• MW: 466.28
• Purity: 99.41% (May vary between batches)
• Formula: C₂₂H₁₆BrN₃O₄
• SMILES: N(C(=O)C1=CC(N(=O)=O)=CC=C1Br)C=2C=C3C(OC(=N3)C4=CC=C(CC)C=C4)=CC2
• Target: PPAR
• Solubility: DMSO:90 mg/mL (193.02 mM)

Bioactivity

• Target IC50:
  CYP2C8:4.3 μM|PPARγ (rat):24 nM|PPARγ (human):6.3 nM
• In Vivo:
  BAY-0069 (1 μM; 1 h) exhibits superior microsomal stability, with a CL(b,hmic) of 0.47 L/h/kg in human liver microsomes and a CL(b,rhep) of 3.9 L/h/kg in rat liver hepatocytes.
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• In Vitro:
  BAY-0069 (0.0001, 0.001, 0.01, 0.01 and 1 μM; 7 days) leads to antiproliferative effects in the PPARγ-amplified cell line UM-UC-9.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CompoundBAY0069, BAY 0069, BAY0069, BAY-0069, PPARγ

Compound Identifiers

PubChem CID

2298593