Coibamide A

SKU: orb1980937

Description

Coibamide A is a cytotoxic N-methyl-stabilized depsipeptide that exhibits potent antiproliferative effects. It induces mTOR-independent autophagy and apoptosis while inhibiting VEGFA/VEGFR2 signaling, demonstrating efficacy in suppressing glioblastoma tumor growth in both in vitro and in vivo xenograft models.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• Target: Apoptosis,Autophagy,VEGFR
• CAS Number: 1029227-48-2
• MW: 1287.63
• Formula: C₆₅H₁₁₀N₁₀O₁₆
• SMILES: [H][C@@]1([C@@H](C)CC)N(C)C(=O)[C@H](COC)N(C)C(=O)[C@H]([C@@H](C)OC(=O)[C@@H](C)N(C)C(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C)NC1=O)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](COC)N(C)C(=O)[C@H](OC(=O)[C@H](C(C)C)N(C)C)C(C)C

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

145963995