COG 133

SKU: orb654723

Description

COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC50 of 445 nM[1][2].Substantially reduces the symptoms of experimental autoimmune encephalomyelitis, a model of human multiple sclerosis, and suppresses inflammation, demyelination and infiltration of cells into the spinal cord. Also acts as a non-competitive antagonist at α7 nicotinic acetylcholine receptors (IC50 = 445 nM).

Key Properties

• CAS Number: 514200-66-9
• MW: 2283.78
• Formula: C₉₉H₁₈₂F₃N₃₇O₂₁
• SMILES: [Ac-LRVRLASHLRKLRKRLL-NH2]

Storage & Handling

• Disclaimer: For research use only