CNS-5161 hydrochloride

SKU: orb1710013

Description

CNS-5161 hydrochloride

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 160756-38-7
• MW: 388.38
• Purity: 99.69%
• Formula: C₁₆H₁₉Cl₂N₃S₂
• SMILES: Cl.ClC1=CC=C(SC)C=C1NC(=N)N(C=2C=CC=C(SC)C2)C
• Target: NMDAR,iGluR
• Solubility: DMSO:245 mg/mL (630.83 mM)

Bioactivity

• Target IC50:
  NMDA:1.8 nM (Ki)
• In Vivo:
  In the neonatal rat NMDA excitotoxicity model in vivo, CNS-5161 (i.p.) protects against the necrotic effects of exogenous N-methyl-D-aspartate (ED80: 4 mg/kg). CNS-5161 also demonstrates a 91% inhibition of audiogenic seizures in DBA/2 mice at 4 mg/kg i.p. and exhibits neuroprotective effects following hypoxic/ischaemic brain injury in neonatal rats.
• In Vitro:
  CNS-5161 has potent inhibitory activity in vitro at the NMDA ion channel and is able to displace [3H] MK-801 binding with a Ki of 1.8 nM in synaptosomal membrane preparations from rat brain.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CNS 5161 Hydrochloride, CNS 5161A, CNS5161 Hydrochloride, CNS-5161 Hydrochloride, NMDA receptor/ion channel, NMDA

Compound Identifiers

PubChem CID

9886565