CNQX disodium

SKU: orb1298918

Description

CNQX disodium salt is a selective, competitive antagonist of AMPA and kainate subtypes of ionotropic glutamate receptors. It is widely used in both in vitro and in vivo neuroscience research to study excitatory synaptic transmission, neuronal excitability, and mechanisms of neuroprotection.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 479347-85-8
• MW: 276.12
• Purity: 97.77% (May vary between batches)
• Formula: C₉H₂N₄Na₂O₄
• SMILES: [Na+].[Na+].[O-]c1nc2cc(C#N)c(cc2nc1[O-])[N+]([O-])=O
• Target: iGluR
• Solubility: DMSO:25 mg/mL (90.54 mM)

Bioactivity

• Target IC50:
  AMPA:0.3 μM (IC50)|Kainate receptor:1.5 μM (IC50)
• In Vivo:
  The ED50 for CNQX was 45.9+/-4.65 microg, respectively. Intrathecal injection of a combination of CNQX and gabapentin produced a strong synergistic antiallodynic effect in neuropathic rats.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FG9065 disodium, fear-potentiated, Inhibitor, iGluR, kainate, non-NMDA, Ionotropic glutamate receptors, inhibit, CNQX, CNQX disodium, AMPA, AMPAR, startle

Compound Identifiers

PubChem CID

6093155