CMP8

SKU: orb1308437

Description

CMP8 is a selective estrogen receptor ligand with high affinity for mutant ER-LBD, exhibiting IC50 values of 29 nM (MGERα), 41 nM (MGRERα), 1100 nM (hERα), and 2200 nM (hERβ). This small molecule is a valuable research tool for investigating ER function and selectivity in both cellular and biochemical assays.

Research Area

Metabolism Research

Key Properties

• CAS Number: 851107-28-3
• MW: 528.08
• Purity: 99.38% (May vary between batches)
• Formula: C₃₃H₃₄ClNO₃
• SMILES: C(C12C(C=3C(C1)=CC(O)=CC3)=C(C(=O)CC2)C4=CC=C(OCCN5CCCCC5)C=C4)C6=CC=C(Cl)C=C6
• Target: Estrogen/progestogen Receptor,Estrogen Receptor/ERR
• Solubility: DMSO:50 mg/mL (94.68 mM)

Bioactivity

• Target IC50:
  MGERα:29 nM|MGRERα:41 nM|ERα (human):1100 nM|ERβ (human):2200 nM
• In Vivo:
  CMP8 is dosed in male Balb-c mice (4 mg/kg, ip). In mammalian cells, the plasma concentration after 4 h is 1.5-fold its EC50. It has a Cmax of 0.5 μM after 30 min.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CMP 8, CMP8, CMP-8, ERR, Estrogen Receptor, EstrogenReceptor, Estrogen Receptor/ERR, Inhibitor, hERα, hERβ, inhibit, MGERα, MGRERα, progestogenReceptor, progestogen Receptor

Compound Identifiers

PubChem CID

16082575