CMP3a

SKU: orb1700829

Description

CMP3a is a potent and selective NEK2 kinase inhibitor that suppresses glioblastoma (GBM) growth in vivo and synergizes with radiotherapy. Its mechanism involves targeting NEK2 to destabilize the histone methyltransferase EZH2, thereby overcoming therapeutic resistance in GBM models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2225902-88-3
• MW: 568.61
• Formula: C₂₈H₂₇F₃N₆O₂S
• SMILES: O([C@@H](C)C1=C(C(F)(F)F)C=CC=C1)C=2C=C(C=3N4C(=NC3)C=C(C=C4)C5=CN(CCN(C)C)N=C5)SC2C(N)=O
• Target: MAPK,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

134470188