CM-675

SKU: orb1710023

Description

CM-675 is a dual-target small molecule inhibitor of PDE5 and class I HDACs, exhibiting IC50 values of 114 nM and 673 nM against PDE5 and HDAC1, respectively. It has shown potential in Alzheimer's disease research, with studies indicating neuroprotective effects and cognitive improvement in preclinical in vivo models.

Research Area

Epigenetics & Chromatin, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 1872466-47-1
• MW: 536.62
• Purity: 99.67% (May vary between batches)
• Formula: C₃₁H₃₂N₆O₃
• SMILES: CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(Cc2ccc(cc2)C(=O)Nc2ccccc2N)ccc1OCC
• Target: HDAC,PDE
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.86 mM);DMSO:22.5 mg/mL (41.93 mM)

Bioactivity

• Target IC50:
  HDAC1:673 nM (30 min (time-dependent))|PDE5:114 nM nM
• In Vitro:
  CM-675 (29a) demonstrates a pronounced time-dependent inhibitory effect on class I HDACs, particularly HDAC2. Its potency against HDAC1 also significantly enhances over time, showing increased inhibition (~1 log unit) at varying pre-incubation intervals: 673 nM at 30 minutes, 180 nM at 4 hours, and 69 nM at 6 hours.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CM675, CM-675, CM 675, PDE5

Compound Identifiers

PubChem CID

136955224