CLP290

SKU: orb1301786

Description

CLP290

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1181083-81-7
• MW: 404.46
• Purity: 100.00%
• Formula: C₁₉H₂₁FN₄O₃S
• SMILES: Fc1ccc(\C=C2/SC(=NC2=O)N2CCCCN2)c(OC(=O)N2CCCC2)c1
• Target: Potassium Channel
• Solubility: DMSO:12 mg/mL (29.67 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.94 mM)

Bioactivity

• In Vivo:
  In vivo co-treatment with morphine and oral CLP290 prevented membrane KCC2 downregulation in SDH neurons. Concurrently, co-treatment with CLP290 significantly mitigated MIH and acute administration of CLP257 in established MIH restored normal nociceptive behavior.
• Animal Research:
  Morphine sulfate (50 mg/ml) was diluted in saline sterile solution immediately before injection. Morphine or saline were subcutaneously injected twice a day (10 mg/kg; 9 a.m. 6 p.m.) in na ve adult rats. The KCC2 enhancer CLP257 and its carbamate pro-drug CLP290 were freshly diluted in 20% 2-hydroxypropyl-β-cyclodextrin (HPCD) prior injection. CLP257 or vehicle were delivered intraperitoneally after 7 8 days of morphine or saline, as described (100 mg/kg). CLP290 or vehicle were delivered orally by gavage twice a day for the whole duration of the morphine/saline treatment (100 mg/kg).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KcsA, Inhibitor, KCC2, inhibit, CLP 290, CLP-290, CLP290, PotassiumChannel, Potassium Channel

Compound Identifiers

PubChem CID

44188755