Clorsulon

SKU: orb1309639

Description

Clorsulon is a benzenedisulfonamide anthelmintic compound used in research for treating Fasciola hepatica (liver fluke) infections. It is applied in veterinary parasitology studies, serving as a critical tool for both in vivo animal model research and in vitro pharmacological investigations against trematodes.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 60200-06-8
• MW: 380.66
• Purity: 99.87%
• Formula: C₈H₈Cl₃N₃O₄S₂
• SMILES: C(=C(Cl)Cl)(Cl)C1=C(S(N)(=O)=O)C=C(S(N)(=O)=O)C(N)=C1
• Target: ATPase,Parasite,Antibiotic
• Solubility: DMSO:71 mg/mL (186.52 mM);Ethanol:7 mg/mL (18.39 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.25 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  ATP:0.29 mM(ki)|3-phosphoglycorate:0.29 mM(ki)
• In Vivo:
  Clorsulon is a competitive inhibitor (Ki=0.29 mM) of both 3-phosphoglycerate and ATP, capable of suppressing glucose utilization and the formation of acetate and propionate.
• In Vitro:
  In sheep and calves, a single administration of Clorsulon (15 mg/kg) effectively induces damage to the cortical and intestinal tissues of the liver flukes, thereby expelling immature liver flukes from the host organism.

Storage & Handling

• Storage: keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MK 401, MK401, MK-401, Parasite, Inhibitor, inhibit, L 631529, L631529, L-631529, gigantica, Flukicidal, Fasciola, glucose utilization, Clorsulon, 3-phosphoglycorate, Antibiotic, ATP

Compound Identifiers

PubChem CID

43231