Clofarabine

SKU: orb1310747

Description

Clofarabine

Research Area

Cell Biology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 123318-82-1
• MW: 303.68
• Purity: 100.00% (May vary between batches)
• Formula: C₁₀H₁₁ClFN₅O₃
• SMILES: Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F
• Target: Apoptosis|||Nucleoside Antimetabolite/Analog|||Autophagy|||DNA/RNA Synthesis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.59 mM);DMSO:245 mg/mL (806.77 mM)

Bioactivity

• Target IC50:
  Ribonucleotide reductase:65 nM
• In Vivo:
  In lymphocytes from chronic lymphocytic leukemia, 10 μM Clofarabine inhibits the repair induced by 4-hydroperoxycyclophosphamide with a peak inhibition at an intracellular concentration of 5 μM. Across a range of leukemia and solid tumor cell lines, Clofarabine demonstrates potent growth inhibition and cytotoxicity (IC50= 0.028–0.29 μM).
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• In Vitro:
  In athymic nude mice or severe combined immunodeficient (SCID) mice, Clofarabine demonstrates inhibitory effects on various subcutaneously transplanted human tumor xenografts.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RNASynthesis, RNA Synthesis, ribonucleotide reductase, RR, Evoltra, inhibit, Inhibitor, Nucleoside Antimetabolite, Nucleoside Antimetabolite/Analog, nucleoside, NucleosideAntimetabolite, DNASynthesis, DNA Synthesis, Clolar, Clofarabine, Clofarex, Autophagy, Analog, analogue, Apoptosis

Compound Identifiers

PubChem CID

119182