Clindamycin

SKU: orb1225864

Description

Clindamycin inhibits protein synthesis by acting on the 50S ribosomal.

Key Properties

• CAS Number: 18323-44-9
• MW: 424.98
• Purity: >98% (HPLC)
• Formula: C₁₈H₃₃ClN₂O₅S
• SMILES: CCC[C@@H]1C[C@@H](C(N[C@@H]([C@H]2O[C@@H]([C@@H]([C@H]([C@H]2O)O)O)SC)[C@@H](Cl)C)=O)N(C1)C
• Target: Others
• Solubility: DMSO:85 mg/mL (200.0 mM); Ethanol:85 mg/mL (200.0 mM); Water:<1 mg/mL (<1 mM)

Bioactivity

• In Vitro:
  Cell Viability Assay Cell line: THP-1 cells with stimulated E. coli O55: B5 Concentration: 3.13-50 μg/mL Incubation time: 1-18 h. Result: Reduced TNF-α concentrations after pretreatment for 4 or 18 h at 25 and 50 μg/mL. Cell Viability Assay Cell line: Osteoblast cell culture model. Concentration: 0-500 μg/mL. Incubation time: 24-72 h. Result: Increased alkaline phosphatase (ALP)-activity at 10 μg/mL at 24 and 48 h. Increased LDH values at 500 μg/mL at 24 and 48 h, indicating cytotoxicity. Increased calcification at 10 and 25 μg/mL, decreased or no calcification was found at 50 μg/ml.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

U 21251

Quick Database Links

Gene Symbol

Others