CLIK-148

SKU: orb3173595

Description

CLIK-148 is an oral, highly selective, irreversible inhibitor of cysteine protease that primarily targets cathepsin L. It effectively impedes the cathepsin L-dependent degradation of HMG-CoA reductase on the endoplasmic reticulum (ER) membrane. Additionally, CLIK-148 inhibits the cathepsin L-mediated processing of procholecystokinin (proCCK), leading to reduced production of CCK8. By obstructing cathepsin L degradation of type I collagen secreted by osteoclasts, CLIK-148 decreases tumor-induced bone metastasis and malignant hypercalcemia. This compound is valuable for research into bone metabolism disorders and neuropeptide processing regulation.

Key Properties

• CAS Number: 215098-90-1
• MW: 410.47
• Formula: C₂₂H₂₆N₄O₄
• SMILES: C(N[C@@H](CC1=CC=CC=C1)C(N(C)C)=O)(=O)[C@@H]2[C@@H](C(NCCC3=CC=CC=N3)=O)O2
• Target: Cysteine Protease,Cholecystokinin Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Cysteine Protease,Cholecystokinin Receptor