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CL2A

SKU: orb2279250

Description

CL2A is a pH-sensitive, cleavable linker featuring a PEG8 spacer and a self-immolative PABC system, connected via a triazole moiety. It enables antibody-drug conjugation through a disulfide bond and is designed to release potent payloads with a bystander effect, as utilized in the ADC labetuzumab govitecan for targeted cancer therapy research.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1846605-04-6
MW1106.22
FormulaC51H79N9O18
SMILESC(C1CCC(C(NCC2=CN(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(COCC(N[C@H](C(NC3=CC=C(COC(O)=O)C=C3)=O)CCCCN)=O)=O)N=N2)=O)CC1)N4C(=O)C=CC4=O
TargetADC Linker,PROTAC Linker

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

CL2A (orb2279250)

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