CL 316243

SKU: orb1710036

Description

CL 316243

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 138908-40-4
• MW: 465.79
• Purity: 99.68%
• Formula: C₂₀H₁₈ClNNa₂O₇
• SMILES: [Na+].[Na+].C[C@H](Cc1ccc2OC(Oc2c1)(C([O-])=O)C([O-])=O)NC[C@H](O)c1cccc(Cl)c1
• Target: Adrenergic Receptor
• Solubility: DMSO:10 mg/mL (21.47 mM);H2O:100 mg/mL (214.69 mM)

Bioactivity

• Target IC50:
  β3-adrenoceptor:3 nM (EC50)
• In Vivo:
  METHODS: The relaxant effects of different concentrations of CL316243 (0.25-100 g/kg) on the rat lower esophageal sphincter (LES) were recorded before and after continuous infusion of L748337 (0.5 g kg1 min1). RESULTS CL316243 had a significant, long-term and dose-dependent inhibitory effect on LESP, with little effect on heart rate and mean arterial pressure.
• In Vitro:
  METHODS: We treated rat adipocytes with CL (0.001 - 1 μM) and examined MAPK activation. RESULTS Treatment of cells with CL for 15 min activated MAPK, but the increase in MAPK activation was not obvious when treated with 1 nM CL, and disappeared when the concentration of CL was increased to 1 μM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Adrenergic Receptor, AdrenergicReceptor, CL-316243, CL316243, CL 316243, Beta Receptor, Inhibitor, inhibit, β3-adrenoceptor

Compound Identifiers

PubChem CID

5312115