Citalopram hydrobromide

SKU: orb1308515

Description

Citalopram hydrobromide

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 59729-32-7
• MW: 405.304
• Purity: 99.35%
• Formula: C₂₀H₂₂BrFN₂O
• SMILES: Br.CN(C)CCCC1(OCc2cc(ccc12)C#N)c1ccc(F)cc1
• Target: 5-HT Receptor,Autophagy,Serotonin Transporter
• Solubility: DMSO:55 mg/mL (135.7 mM);Ethanol:6 mg/mL (14.8 mM);H2O:4.09 mg/mL (10.09 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.93 mM)

Bioactivity

• Target IC50:
  5 hT receptor:1.8 nM
• In Vivo:
  Citalopram is devoid of cardiotoxic effects even when animals are exposed to concentration far abov the therapeutic level. In man citalopram is metabolized to compounds which are also potent 5 hT-uptake inhibitors without effect on noradrenaline(NA) uptake and which are found in lower concentration than citalopram itself. Citalopram (1-16 mg/kg) stimulate the hind limb flexor reflex in the spinal rat. Citalopram potentiates 5 hT transmission~ possibly by producing very strong uptake Inhibition without simultaneously blockin the post-synaptic 5 hT receptor.
• In Vitro:
  Citalopram (Lu 10-171), a new bicyclic phthalane derivative, is an extremely potent inhibitor of neuronal serotonin (5 hT) uptake but has no effect o the uptake of noradrenaline(NA) and dopamine (DA) and no antagonistic activity towards 5 hT, histamine, gamma aminobutyric acid (GABA), acetylcholine, and morphine receptors. It is an extremely specific and potent inhibitor of neuronal 5 hT uptake. Uptake mechanisms for Other transmitter amines are not influenced b the dru the SSRI citalopram has a greater effect on proliferation and a lesser effect on apoptotic activity. It affects cell cycle regulation by increasing Proliferative potential and decreasing apoptotic activity in a site specific manner that may be indicative of hyperplasia. Citalopram alters FGF, MSX and TGFB expression in osteoblast cell cultur.
• Cell Research:
  Cells are cultured in alpha minimum Eagles medium supplemented with 1% penicillin/streptomycin, 10% fetal bovine serum and Amphotericin B. For control data, cells are cultured for 3 or 7 days with s andard alpha proliferation media. For SSRI treatments, media is supplemented with citalopram eluted to serially diluted doses between 10^-4 mol through 10^-10 mol to achieve a dose response curve.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Lu 10-171, Lu 10-171 HBr, Nitalapram HBr, Citalopram, Citalopram HBr, 5-HT, 5HTReceptor, (±)-Citalopram, 5-HT,Antidepressant, 5HT Receptor, Bonitrile HBr, Autophagy, SSRI, Serotonin Transporter, SerotoninTransporter

Compound Identifiers

PubChem CID

77995