Ciprofloxacin

SKU: orb1307927

Description

Ciprofloxacin

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 85721-33-1
• MW: 331.34
• Purity: 99.22%
• Formula: C₁₇H₁₈FN₃O₃
• SMILES: OC(=O)C1=CN(C2CC2)C2=C(C=C(F)C(=C2)N2CCNCC2)C1=O
• Target: Antibacterial,Reactive Oxygen Species,Antibiotic,Apoptosis,Topoisomerase,Mitochondrial Metabolism
• Solubility: H2O:Insoluble;DMSO:0.33 mg/mL (1 mM);0.1 M HCL:55 mg/mL (165.99 mM);0.1 M HCl:55 mg/mL (165.99 mM)

Bioactivity

• Target IC50:
  B. anthracis:0.12 μg mL (MIC90)|GABAA: 50 μM|Y. pestis:0.03 μg mL (MIC90)|Korschikov:6700 μg/L
• In Vivo:
  METHODS: To stud the preventive effect of Ciprofloxacin against plague, mice were intraperitoneally injected with Ciprofloxacin (30 mg/kg) for 24 hours. Results: Ciprofloxacin could prevent Yersinia pestis in a mouse model of pneumonic plague. METHODS: To investigat the effect of Ciprofloxacin o the susceptibility to aortic dissection and rupture in mice, Ciprofloxacin (100 mg/kg) was administered intraperitoneally once daily for 4 weeks. Results: Ciprofloxacin accelerated aortic root dilation and increase the incidence of aortic dissection and rupture by decreasing LOX levels and increasing MMP levels and activity in the aortic wall. Ciprofloxacin induces DNA damage and release of DNA int the cytoplasm, mitochondrial dysfunction, and activation of cytoplasmic DNA sensor signals. Ciprofloxacin increased apoptosis and necroptosis in the aortic wall.
• In Vitro:
  METHODS: Prostate cancer cells (LNCaP and DU145) were treated with Ciprofloxacin, an the cytotoxicity was detected by lactate dehydrogenase (LDH) release assay. Results: Ciprofloxacin showed low cytotoxicity to DU145 cells, with a LDH release rate of 23.3% the release rate of LDH to LNCaP cells was 22.1%. METHODS: Tenocytes were treated with Ciprofloxacin (5-50 μg/ml) for 0-24 hours, and MTT assay was used to detect cell growth inhibition. Results: Ciprofloxacin inhibited cell proliferation and induced cell cycle arrest at G2/M phase. METHODS: Minimum inhibitory concentration of Yersinia pestis and Bacillus anthracis were determined after treatment with Ciprofloxacin. Results: Ciprofloxacin showed potent activity against Yersinia pestis and Bacillus anthracis with MIC90 of 0.03 μg mL and 0.12 μg/ml, respectively

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Bay 09867, Bay09867, Bay-09867, Bay o 9867, Bacterial, Antibiotic, anti-proliferative, Apoptosis, Ciproxan, Ciprobay, Ciprofloxacin, DNA, DNA damage, Inhibitor, Mitochondrial Metabolism, mitochondrial, inhibit, Reactive Oxygen Species, ROS, Topo II, Topo IV, Topoisomerase

Compound Identifiers

PubChem CID

2764