Cinobufotalin

SKU: orb1219102

Description

Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide production. Cinobufotalin is also an effective reversal agent for the multidrug resistance of tumors, it can reverse the adriamycin-resistance in Raji/ADR cells and the expression of P-gp and MRP-1 proteins. Cinobufotalin can promote the dendritic cells(DCs) derived from peripheral blood of patients with chronic hepatitis B to mature and effectively enhance its(the DCs') capabilities, therefore the treatment of cinobufotalin may potentiate the antiviral immunity of the patients with chronic hepatitis B(CHB).

Key Properties

• CAS Number: 1108-68-5
• MW: 458.54
• Purity: >98% (HPLC)
• Formula: C₂₆H₃₄O₇
• SMILES: C[C@]([C@@H](C(C=C1)=COC1=O)[C@H]2OC(C)=O)(CC[C@@]3([H])[C@@]4([H])CC[C@@]5(O)[C@@]3(CC[C@H](O)C5)C)[C@@]64[C@@H]2O6
• Target: Akt
• Solubility: DMSO:35 mg/mL (76.33 mM)

Bioactivity

• In Vivo:
  Animal model: Male nude mice (4-6 weeks old, BALB/c) with A549 cells. Dosage: 1 mg/kg or 5 mg/kg. Administration: Intraperitoneal injection; twice daily; for 1 weeks. Result: Inhibited A549 lung cancer cell growth In vivo.
• In Vitro:
  Cell Cytotoxicity Assay Cell line: A549, H460 and HTB-58 human lung cancer cells. Concentration: 0.1 μM, 0.5 μM, 1 μM, 5 μM, 10 μM Incubation time: 72 hours. Result: Significantly induced cell death in a concentration-dependent manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Akt