Cinnamtannin D1

SKU: orb3179501

Description

Cinnamtannin D1 is an orally active polyphenolic compound that modulates the Th17/Treg cell balance by inhibiting AHR expression. It reduces apoptosis and ROS in INS-1 cells and primary cultured mouse islets induced by Palmitic acid (PA). Cinnamtannin D1 mitigates Th17 cell differentiation by downregulating p-STAT3/RORγt and enhances Treg cell differentiation by upregulating p-STAT5/Foxp3. In a collagen-induced arthritis (CIA) mouse model, it demonstrates excellent anti-arthritic efficacy. Cinnamtannin D1 is applicable for rheumatoid arthritis (RA) research.

Key Properties

• CAS Number: 97233-06-2
• MW: 864.77
• Formula: C₄₅H₃₆O₁₈
• SMILES: O[C@H]1[C@@]2(OC3=C([C@]1(C=4C(O2)=CC(O)=CC4O)[H])C5=C(C(O)=C3)[C@@H]([C@@H](O)[C@H](O5)C6=CC(O)=C(O)C=C6)C7=C8C(C[C@H](O)[C@H](O8)C9=CC(O)=C(O)C=C9)=C(O)C=C7O)C%10=CC(O)=C(O)C=C%10
• Target: STAT,ROS,Apoptosis

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

STAT,ROS,Apoptosis