Cilobradine hydrochloride

SKU: orb1710048

Description

Cilobradine hydrochloride

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 186097-54-1
• MW: 519.07
• Purity: 98.40%
• Formula: C₂₈H₃₉ClN₂O₅
• SMILES: Cl.COc1ccc(CCN2CCC[C@H](CN3CCc4cc(OC)c(OC)cc4CC3=O)C2)cc1OC
• Target: HCN Channel
• Solubility: DMSO:112.5 mg/mL (216.73 mM);H2O:91 mg/mL (175.31 mM)

Bioactivity

• In Vitro:
  Cilobradine hydrochloride is an HCN channel blocker that is about 3 times more potent than ZD7288. At a concentration of 10 μM, Cilobradine hydrochloride inhibits WT mHCN2 channel current by 86%. In contrast, I432A and A425G channel currents were only reduced by 14% and 19%, respectively, by this concentration of Cilobradine hydrochloride. The double mutant (I432A/A425G) channel was even less sensitive to 10 μM Cilobradine hydrochloride (8 ± 2% inhibition).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HCN Channel, HCNChannel, Cilobradine Hydrochloride, DK-AH 269, DK-AH269, DK-AH-269

Compound Identifiers

PubChem CID

16078969