Chromocarb

SKU: orb1310784

Description

Chromocarb (Chromone-2-carboxylic acid) is a small molecule with vascular protective properties, utilized in research on venous and microvascular disorders. Its applications include in vitro studies on endothelial function and in vivo models investigating its potential therapeutic effects for vascular pathologies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 4940-39-0
• MW: 190.15
• Purity: 99.91% (May vary between batches)
• Formula: C₁₀H₆O₄
• SMILES: OC(=O)C1=CC(=O)C2=C(O1)C=CC=C2
• Target: Others
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:50 mg/mL (262.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (10.52 mM)

Bioactivity

• In Vitro:
  Rats treated orally with Chromocarb exhibited a significant reduction in vascular wall degradation induced by intravenous collagenase. Chromocarb treatment led to a decreased increase in BBB (blood-brain barrier) permeability, accelerated recovery, lower hydroxyproline levels in cerebrospinal fluid, and a lesser decline in collagen content within the cerebral capillary basement membranes. Furthermore, at a dose of 50 mg/kg, Chromocarb was more effective than vitamin C at preventing the oxidation of reduced glutathione in the blood.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Chromocarb, Chromocarbe, Chromone-2-carboxylic acid, Inhibitor, inhibit

Compound Identifiers

PubChem CID

2741