Chlorphenesin

SKU: orb1222907

Description

Chlorphenesin is an antigen-associated immunosuppressant that inhibits IgE-mediated histamine release. It is also used as an antimycotic agent.(In Vitro):Chlorphenesin (0.01, 0.1, 0.3%; 30-min exposure) significantly reduces the activity of the Akt pathway in a dose-dependent manner in human meibomian gland epithelial cells (HMGECs).Chlorphenesin (0.1, 0.3%; 24 hours) induces immortalized HMGECs (IHMGECs) rounding, atrophy, poor adherence, detachme and significantly reduces the number of IHMGECs.

Key Properties

• CAS Number: 104-29-0
• MW: 202.63
• Purity: >98% (HPLC)
• Formula: C₉H₁₁ClO₃
• SMILES: OCC(O)COc1ccc(Cl)cc1
• Target: NF-κB
• Solubility: In Vitro: DMSO : 100 mg/mL (493.51 mM)

Bioactivity

• In Vitro:
  Chlorphenesin (0.01, 0.1, 0.3%; 30-min exposure) significantly reduces the activity of the Akt pathway in a dose-dependent manner in human meibomian gland epithelial cells (HMGECs). Chlorphenesin (0.1, 0.3%; 24 hours) induces immortalized HMGECs (IHMGECs) rounding, atrophy, poor adherence, detachme and significantly reduces the number of IHMGECs.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Chlorphenesin | NSC 6401 | NSC6401 | NSC-6401

Quick Database Links

Gene Symbol

NF-κB