Chloroquinoxaline sulfonamide

SKU: orb1707455

Description

Chloroquinoxaline sulfonamide

Research Area

Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 97919-22-7
• MW: 334.78
• Purity: 98.00% (May vary between batches)
• Formula: C₁₄H₁₁ClN₄O₂S
• SMILES: Nc1ccc(cc1)S(=O)(=O)Nc1cnc2c(Cl)cccc2n1
• Target: Topoisomerase,Parasite,Molecular Glues
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.95 mM);DMSO:100 mg/mL (298.7 mM)

Bioactivity

• Target IC50:
  CV-1 cells:1.8 mM
• In Vitro:
  Chloroquinoxaline sulfonamide-induced protein-DNA cross-links and topoisomerase II-DNA cross-links in CV-1 cells . Chloroquinoxaline sulfonamide inhibits the proliferation of mouse B16 melanoma cells, but only when a relatively high drug concentration (1 mM) is used . The IC50 value of chloroquinoxaline sulfonamide on CV-1 cells was 1.8 mM using MTT cytotoxicity assay.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Chloroquinoxaline, Chloroquinoxaline sulfonamide, NSC 339004, NSC339004, NSC-339004, Topo II, topoisomerase II beta, topoisomerase II alpha

Compound Identifiers

PubChem CID

72462