Chlorantraniliprole

SKU: orb1689816

Description

Chlorantraniliprole

Key Properties

• CAS Number: 500008-45-7
• MW: 483.15
• Purity: 98.86%
• Formula: C₁₈H₁₄BrCl₂N₅O₂
• SMILES: CNC(=O)c1cc(Cl)cc(C)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl
• Target: Others
• Solubility: DMSO:56.7 mg/mL (117.35 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.14 mM)

Bioactivity

• In Vivo:
  Chlorantraniliprole exhibits low acute toxicity in mammals, with rats demonstrating an acute oral LD50 exceeding 5000 mg/kg. Additionally, it shows minimal to no toxicity in 90-day studies, even when administered at doses up to 1500 mg/kg/day.
• In Vitro:
  Chlorantraniliprole potently and selectively activates insect ryanodine receptor. Chlorantraniliprole actions by release of intracellular Ca2+ stores mediated by the ryanodine receptor. Chlorantraniliprole is ∼300-fold less potent against ryanodine receptor (RyRs) in the mouse myoblast cell line, C2C12 (EC50, 14 μM), than in insect RyRs from Drosophila melanogaster and H. virescens (EC50, 40 nM, 50 nM), and shows little selectivity at the rat cell line RyR2 (EC50, >100 μM).

Storage & Handling

• Storage: keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

insecticide, Chlorantranilipole, Chlorantraniliprole, Rynaxpyr, Rynaxypyr, Ryanodine receptor

Compound Identifiers

PubChem CID

11271640