CHDI-390576

SKU: orb1707458

Description

CHDI-390576 is a potent, selective, and brain-penetrant inhibitor of class IIa HDACs (HDAC4, 5, 7, 9). This dibenzoyl isohydroxamic acid compound is a valuable research tool for investigating the role of these HDACs in oncology, supporting both in vitro and in vivo experimental models.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1629729-98-1
• MW: 391.32
• Purity: ≥98% (May vary between batches)
• Formula: C₁₉H₁₃F₄N₃O₂
• SMILES: ONC(=O)C(c1ccc(cc1)-c1ncc(cn1)C(F)(F)F)c1ccccc1F
• Target: HDAC
• Solubility: DMSO:200 mg/mL (511.09 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (12.78 mM)

Bioactivity

• Target IC50:
  HDAC1:39.7 μM|HDAC4:54 nM|HDAC5:60 nM|HDAC7:31 nM|HDAC6 (human):6.2 μM|HDAC8:9.1 μM|HDAC3:25.8 μM|HDAC9 (human):50 nM
• In Vitro:
  CHDI-390576 exhibits good affinity to the catalytic domain of HDAC4, and it inhibits class I HDACs (1, 3, 8) and class IIb HDAC6.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HDAC7, HDAC8, HDAC5, HDAC, HDAC3, HDAC4, HDAC1, hHDAC6, hHDAC9, CHDI 390576, CHDI390576, CHDI-390576

Compound Identifiers

PubChem CID

81689842