CHDI 00484077

SKU: orb1979927

Description

CHDI-00484077 is a brain-penetrant, selective Class IIa HDAC inhibitor targeting HDAC4, 5, 7, and 9. It is a research tool for studying Huntington's disease, shown to enhance neuronal function in both cellular and animal models of the disorder.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 3025894-92-9
• MW: 382.39
• Formula: C₁₈H₂₁F₃N₄O₂
• SMILES: O=C(C1=CC=C(C=C1)C2=NOC(C(F)(F)F)=N2)N[C@@H](CN3[C@H](CCC3)C)C
• Target: Others

Bioactivity

• Target IC50:
  HDAC3:10 μM|HDAC6:22 μM|HDAC8:2 μM|HDAC1:17 μM|HDAC4:0.01 μM|HDAC5:0.02 μM|HDAC9:0.03 μM|HDAC7:0.02 μM|HDAC2:27 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CHDI00484077

Compound Identifiers

PubChem CID

162675553