Ch55

SKU: orb1308458

Description

Ch55 (3,5-Di-tert-butylchalcone) is a potent RAR-α/β agonist that induces HL60 cell differentiation with an EC50 of 200 nM. It serves as a valuable research tool for studying retinoic acid receptor signaling in cancer research, including in vitro differentiation assays and related mechanistic studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 110368-33-7
• MW: 364.48
• Purity: 99.55% (May vary between batches)
• Formula: C₂₄H₂₈O₃
• SMILES: CC(C)(C)c1cc(cc(c1)C(C)(C)C)C(=O)\C=C\c1ccc(cc1)C(O)=O
• Target: Retinoid Receptor
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (5.49 mM);DMSO:40 mg/mL (109.75 mM)

Bioactivity

• In Vitro:
  In rabbit tracheal epithelial cells, Ch55 inhibits type I transglutaminase activity (EC50 = 0.02 nM) and increases cholesterol sulfate levels (EC50 = 0.03 nM) thereby inhibiting squamous cell differentiation. Ch55 inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM) and induces cell differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC50 = 0.26 and 0.5 nM). Ch55 shows a low affinity for cellular retinoic acid binding protein.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ch55, Ch-55, CH 55, 3,5-Di-tert-butylchalcone, RARα, RARβ, RetinoidReceptor, Retinoid Receptor

Compound Identifiers

PubChem CID

6184667