CGS 15435

SKU: orb1710074

Description

CGS 15435

Research Area

Immunology & Inflammation, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 95853-92-2
• MW: 356.85
• Purity: 99.40% (May vary between batches)
• Formula: C₂₀H₂₁ClN₂O₂
• SMILES: C(CCCCC(O)=O)C1=C(N(C)C=2C1=CC(Cl)=CC2)C=3C=CC=NC3
• Target: Prostaglandin Receptor,PPAR,Others
• Solubility: DMSO:3.57 mg/mL (10 mM)

Bioactivity

• Target IC50:
  TXA2:1 nM
• In Vivo:
  The effect of CGS 15435 was long lasting, as the increase of plasma TxB2 levels was prevented even 24 hours after the administration of CGS 15435. CGS 15435 inhibited the formation of TxB2 significantly at 4, 6, 12 and 24 h after administration. Administration of CGS 15435 0.25 or 24 h before arachidonic acid (AA) did not increase TxB2 in surviving animals (4/4 and 5/6, respectively). The final TxB2 level in CGS15435A(pretreatment for 0.25 and 24 h) groups was significantly lower than that in arachidonic acid (AA) and daxibon (pretreatment for 2 h) groups.
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• In Vitro:
  CGS 15435 inhibited the formation of PGE2 (IC50:1200 μM), PGI2 synthetase (IC50:90 μM) and 5-lipoxygenase (IC50:60 μM).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CGS 15435, CGS15435, CGS-15435, TXA2, TXA2R

Compound Identifiers

PubChem CID

129519