CGP 20712 A

SKU: orb1710079

Description

CGP 20712 A mesylate is a potent and selective β1-adrenergic receptor antagonist with an IC50 of 0.7 nM. It is utilized in cardiovascular research to study receptor function and has demonstrated in vivo activity, such as reversing gastric relaxation and lowering blood pressure in experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 105737-62-0
• MW: 590.57
• Purity: 99.37% (May vary between batches)
• Formula: C₂₄H₂₉F₃N₄O₈S
• SMILES: O=C(N)C1=CC(OCCNCC(O)COC=2C=CC(=CC2)C3=NC(=CN3C)C(F)(F)F)=CC=C1O.O=S(=O)(O)C
• Target: Adrenergic Receptor
• Solubility: DMSO:80 mg/mL (135.46 mM)

Bioactivity

• Target IC50:
  β1-adrenoceptor:0.7 nM |β1-adrenoceptor:0.7 nM
• In Vivo:
  Pre-treatment with 5mg/kg CGP 20712A (selective β1-adrenoceptor antagonist) in 8-day-old rats did not alter the plasma ACTH response to insulin injection.
• In Vitro:
  In myocyte, saturation experiments conducted in the presence of 300nM CGP 20712A failed to detect specific binding of [125I]-ICYP and [3H]-CGP 12177.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AdrenergicReceptor, Adrenergic Receptor, CGP20712 Mesylate, CGP-20712 Mesylate, CGP 20712 mesylate, CGP 20712 A, β1-adrenoceptor, β1-adrenergic receptor

Compound Identifiers

PubChem CID

10008573