CFTR corrector 12

SKU: orb2277839

Description

CFTR corrector 12 is a research compound that effectively rescues function in a broad range of CFTR mutants, with the notable exception of M760R ABCA3. It serves as a valuable tool for investigating cystic fibrosis disease mechanisms and evaluating therapeutic strategies in both cellular and animal model studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 958941-60-1
• MW: 436.98
• Purity: 99.78% (May vary between batches)
• Formula: C₁₉H₂₁ClN₄O₂S₂
• SMILES: O=C(NC1=NC(=C(S1)C=2N=C(SC2)NC3=CC(Cl)=CC=C3OC)C)C(C)(C)C
• Target: CFTR

Bioactivity

• In Vitro:
  The CFTR corrector 12 , when applied at a concentration of 15 μM for 72 hours, is capable of restoring α-sarcoglycan levels in cells harboring the L31P/V247M α-SG mutations.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CFTR

Compound Identifiers

PubChem CID

11958611