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Cenisertib

SKU: orb1707472

Description

Cenisertib is a potent ATP-competitive multi-kinase inhibitor targeting Aurora kinases, ABL1, AKT, STAT5, and FLT3. It suppresses tumor mast cell growth in vitro and demonstrates broad anti-tumor activity in xenograft models of pancreatic, breast, colon, ovarian, and lung cancers as well as leukemia.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number871357-89-0
MW451.54
FormulaC24H30FN7O
SMILES[H][C@@]12C[C@@]([H])(C=C1)[C@@H]([C@@H]2Nc1nc(Nc2ccc(N3CCN(C)CC3)c(C)c2)ncc1F)C(N)=O
TargetSTAT,Bcr-Abl,Akt,FLT,Aurora Kinase

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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Cenisertib (orb1707472)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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