Cefoselis Sulfate

SKU: orb1300768

Description

Cefoselis sulfate, also known as FK 037 sulfate, is a beta-lactam antibiotic for research use. It is applied in microbiological and pharmacological studies, including in vitro assays against susceptible bacteria and in vivo models of infection.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 122841-12-7
• MW: 620.64
• Purity: 99.90% (May vary between batches)
• Formula: C₁₉H₂₂N₈O₆S₂·H₂SO₄
• SMILES: OS([O-])(=O)=O.[H][C@@]1(NC(=O)C(=N/OC)\c2csc(N)n2)C(=O)N2C(C(O)=O)=C(C[n+]3ccc(N)n3CCO)CS[C@]12[H]
• Target: Antibiotic,Antibacterial
• Solubility: DMSO:27.5 mg/mL (44.31 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.22 mM)

Bioactivity

• In Vivo:
  Cefoselis elicits a massive elevation of extracellular glutamate concentration in normal rats. Cefoselis (50 mg/animal)-induced convulsions are prevented by pretreatment with 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), diazepam and phenobarbital (ED(50) values (mg/kg) of 0.78, 1.59 and 33.0, respectively), but not by carbamazepine or phenytoin.
• In Vitro:
  Cefoselis inhibits GABA-induced currents in a concentration-dependent manner with IC50 of 185 mM. Cefoselis possesses a superior antistaphylococcal activity on MSSA isolates to both other compounds being however equal active to Cefepime and Cefpirome on multiresistant enterobacteriaceae. Cefoselis is dose-dependently appeared in brain extracellular fluid in proportion to its blood level. Cefoselis, a new parenteral cephalosporin, is active against clinical isolates of both gram-positive and gram-negative aerobic bacteria.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cephalosporin, Cefoselis, Cefoselis Sulfate, blood-brain, barrier, Bacterial, antibiotic, Antibiotic, Gram-negative, Gram-positive, FK037, FK-037, FK037 Sulfate, FK-037 Sulfate, FK 037, FK 037 Sulfate, Inhibitor, inhibit, organisms, β-lactam

Compound Identifiers

PubChem CID

9690118