Cefepime

SKU: orb1710673

Description

Cefepime (BMY-28142) is a broad-spectrum fourth-generation cephalosporin antibiotic active against Gram-positive and Gram-negative bacteria, including anaerobic organisms. It is a valuable research tool for studying antimicrobial efficacy and pharmacokinetics in both in vitro and in vivo models, though its potential neurotoxic effects are also an area of investigative interest.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 88040-23-7
• MW: 480.56
• Purity: 99.47% (May vary between batches)
• Formula: C₁₉H₂₄N₆O₅S₂
• SMILES: C([O-])(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC)/C3=CSC(N)=N3)=O)C2=O)(SCC1C[N+]4(C)CCCC4)[H]
• Target: Antibiotic,Antibacterial
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.32 mM);DMSO:120 mg/mL (249.71 mM);H2O:80 mg/mL (166.47 mM)

Bioactivity

• In Vivo:
  METHODS: Mice were given different doses of cisplatin (0, 10, 14, 18, 22, and 26 mg/kg) three days before intraperitoneal (ip) injection of 80 mg/kg cefepime to determine the dose of cisplatin that would not affect mouse survival and achieve human-like serum concentrations of cefepime. RESULTS: The half-life of cefepime was significantly prolonged at cisplatin doses of 18 and 22 mg/kg.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antibiotic, Antibacterial, BMY-28142, Cefepime

Compound Identifiers

PubChem CID

5479537