Cefdinir

SKU: orb1310905

Description

Cefdinir (FK-482) is a third-generation, semi-synthetic cephalosporin antibiotic with broad-spectrum activity. It is utilized in research models for studying its efficacy against bacterial pathogens causing otitis media, sinusitis, and skin infections in both in vitro and in vivo settings.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 91832-40-5
• MW: 395.41
• Purity: 99.89%
• Formula: C₁₄H₁₃N₅O₅S₂
• SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\O)/C3=CSC(N)=N3)=O)C2=O)(SCC1C=C)[H]
• Target: Antibiotic,Glutathione Peroxidase,Antibacterial
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.06 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:40 mg/mL (101.16 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vitro:
  Cefdinir, a new oral 2-amino-5-thiazolyl cephalosporin, inhibits the luminol-amplified chemiluminescence (LACL) response of human neutrophils stimulated by PMA but not opsonized zymosan, in a concentration-dependent but not time-dependent manner. Cefdinir inhibits LACL generation in cell-free systems consisting of Water2, NaI, and either horseradish peroxidase or amyeloperoxidase-containing neutrophil extract. Cefdinir impairs LACL response induced by the calcium ionophore A23187 and FMLP, and this impairment is increased in cytochalasin B-treated neutrophils. Cefdinir directly inhibits the activity of myeloperoxidase-containing neutrophil extract released into the extracellular medium during neutrophil stimulation by soluble mediators, but has no effect on that released into the phagolysosome during phagocytosis. Cefdinir demonstrates excellent activity against a wide range of gram-positive and gram-negative bacteria. Cefdinir is resistant to a broad variety of β-lactamases and exhibits a β-lactam stability profile generally better than those observed with cefaclor and cefuroxime. Cefdinir elimination is primarily mediated by the kidney. Cefdinir interacts with the dipeptide transporters PEPT1 and PEPT2. Cefdinir tubular reabsorption is substantial, that Cefdinir tubular secretion is inhibitable by probenecid, and that this secretion is probably mediated by the renal organic anion secretory pathway.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Glutathione Peroxidase, Gram-negative, Gram-positive, GlutathionePeroxidase, FK482, FK-482, FK 482, MPO, inhibit, PBPs, PD134393, PD-134393, PD 134393, Antibiotic, Bacterial, bacteria, CI983, CI-983, CI 983, cephalosporin, Cefdinir

Compound Identifiers

PubChem CID

6915944