Cedazuridine

SKU: orb1710782

Description

Cedazuridine is an orally bioavailable cytidine deaminase inhibitor with antineoplastic activity. It is used in research, particularly in combination with decitabine, to study its effects on DNA methylation and hematological malignancies in both in vitro and in vivo models.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1141397-80-9
• MW: 268.21
• Purity: 99.46% (May vary between batches)
• Formula: C₉H₁₄F₂N₂O₅
• SMILES: OC[C@H]1O[C@@H](N2CC[C@@H](O)NC2=O)C(F)(F)[C@@H]1O
• Target: Others,DNA Methyltransferase
• Solubility: DMSO:50 mg/mL (186.42 mM)

Bioactivity

• In Vivo:
  Oral Cedazuridine when combined with Azacitidine achieves successful tumor regression in both human cell line-derived xenograft transplantation experiment and patient-derived xenograft models.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cytidine deaminase, DNA Methyltransferase, DNAMethyltransferase, Cedazuridine, 2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine, (4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine

Compound Identifiers

PubChem CID

25267009