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CDK/HDAC-IN-4

SKU: orb2665139

Description

CDK/HDAC-IN-4 is a highly selective dual inhibitor of cyclin-dependent kinase (CDK) and histone deacetylase (HDAC), with IC50 values of 88.4 nM and 168.9 nM, respectively. This compound exhibits antiproliferative effects in both hematologic and solid tumor cells. Additionally, CDK/HDAC-IN-4 induces apoptosis and S-phase cell cycle arrest in MV-4-11 cells. It has also demonstrated significant antitumor efficacy in an MV-4-11 xenograft model.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Images & Validation

Key Properties

TargetHDAC,CDK,Apoptosis

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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Protocol Information

CDK/HDAC-IN-4 (orb2665139)

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