CDK/HDAC-IN-3

SKU: orb1944418

Description

CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3, with IC50 values of 98.32 nM, 98.85 nM, 100 nM, 62.12 nM, 93.28 nM, and 82.87 nM, respectively, and is applicable in the treatment of acute myeloid leukemia (AML).

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2944087-54-9
• MW: 509.34
• Formula: C₂₄H₁₈Cl₂N₆O₃
• SMILES: N(C(=O)C1=C(Cl)C=CC=C1Cl)C=2C(C(NC3=CC=C(C(NC4=C(N)C=CC=C4)=O)C=C3)=O)=NNC2
• Target: CDK,HDAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168355554